PublishYou are here: Home » Products » Business Services » Agency Services » General Trade Agents

Rapamycin of MTOR Inhibitor
Original
price: Negotiable
minimum:
Total supply:
Delivery term: The date of payment from buyers deliver within days
seat: Beijing
Validity to: Long-term effective
Last update: 2021-04-26 14:33
Browse the number: 357
inquiry
Company Profile
 
 
Product details

Research Only! We don’t sell for human use.
Rapamycin, also known as sirolimus or AY-22989, is a specific mTOR inhibitor and has potent immunosuppressive and antiproliferative properties. It is used in coating coronary stents, treatment of lung diseases such as lymphangioleiomyomatosis and preventing organ transplant rejection, especially useful for kidney transplant rejection. By reducing the sensitivity to interleukin-2 (IL-2) through mTOR inhibiting, rapamycin inhibits activation of T cells and B cells.


Cat. No.

53123-88-9

Purity

99.94%

Target

mTOR, Autophagy, Human Endogenous Metabolite

IC50

0.1 nM (IC50, in HEK293 cells )



In Vitro

Lung Cancer Cell Lines: A549, SPC-A-1, 95D and NCI-H446
Incubation Time: 24hours
Concentration at 100 nM: 30-40% reduction in cell proliferation
Concentration at 12.5 nM: ~10% reduction in cell proliferation
* Above data is for reference only. Accuracy is not confirmed.



In Vivo

Animal Model: 24 male nu/nu mice, aged 4-5 week old, weighted 15-20g
Dosage: 2.0mg/kg
Administration: Intraperitoneal injection every other day for 28 days
Result: In monotherapy group, effect of inhibition is moderate. Significantly increased inhibitory effect of tumor growth is achieved when combined with Metformin.
* Above data is for reference only. Accuracy is not confirmed.

Formula

C₅₁HH₇₉NO₁₃

SMILES

O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O

M. Weight

914.2

Storage

Powder: -20°C 3 years
4°C 2 years
In solvent: -80°C 6 months
-20°C 1 month













Solvent & Solubility


Documentation

Contact us for relevant PDF documents.



More Biological Information

http://www.medchemhub.com/

Total0bar [View All]  Related Comments
 
more»Other products
Temsirolimus of MTOR Inhibitor Rapamycin of MTOR Inhibitor Everolimus of MTOR Inhibitor MEK Inhibitor Binimetinib MEK Inhibitor Selumetinib

[ Products search ] [ favorites ] [ Tell friends ] [ Print ] [ Close ]